UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

p57KIP2 immunostaining for diagnosis of hydatidiform mole.

Kaur, B; Sebire, NJ; (2018) p57KIP2 immunostaining for diagnosis of hydatidiform mole. BJOG 10.1111/1471-0528.15330. Green open access

[img]
Preview
Text
Kaur_et_al-2018-BJOG%3A_An_International_Journal_of_Obstetrics_%26_Gynaecology.pdf - Accepted version

Download (208kB) | Preview

Abstract

Accurate diagnosis and sub-classification of hydatidiform moles (HM) and distinction from non-molar (NM) gestations is important, since risk of persistent gestational trophoblastic disease (pGTD) and therefore clinical management differ. P57KIP2 immunostaining has been widely described as an ancillary test to distinguish complete (CHM) and partial (PHM) hydatidiform moles, but cannot discern PHM from non-molar gestations (NM) or identify androgenetic vs biparental CHM, which may be associated with increased recurrence risk. Molecular genotyping (MG) is the gold-standard in these scenarios and also in cases with aberrant/discordant p57KIP2 expression, following which, CHM, PHM and NM can be reliably diagnosed. This article is protected by copyright. All rights reserved.

Type: Article
Title: p57KIP2 immunostaining for diagnosis of hydatidiform mole.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.15330
Publisher version: https://doi.org/10.1111/1471-0528.15330
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10052718
Downloads since deposit
23Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item