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Wnt proteins as modulators of synaptic plasticity

McLeod, F; Salinas, PC; (2018) Wnt proteins as modulators of synaptic plasticity. Current Opinion in Neurobiology , 53 pp. 90-95. 10.1016/j.conb.2018.06.003. Green open access

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Abstract

Dynamic changes in the structure and function of synapses in response to the environment, termed synaptic plasticity, are the cellular basis of learning and memory. At excitatory synapses, activation of NMDA receptors by glutamate leads to calcium influx triggering intracellular pathways that promote the trafficking of AMPA receptors to the post-synaptic membrane and actin remodeling. New evidence shows that Wnt secreted proteins, known for their role in synapse development, are essential for early stages of long-term potentiation, a form of plasticity that increases synaptic strength. Here, we review recent progress in this area and the significance of Wnt signaling to synaptic plasticity in health and disease.

Type: Article
Title: Wnt proteins as modulators of synaptic plasticity
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.conb.2018.06.003
Publisher version: http://doi.org/10.1016/j.conb.2018.06.003
Language: English
Additional information: Copyright Crown Copyright © 2018 Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10052641
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