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Advances in the slow freezing cryopreservation of microencapsulated cells

Gurruchaga, H; Saenz del Burgo, L; Hernandez, RM; Orive, G; Selden, C; Fuller, B; Ciriza, J; (2018) Advances in the slow freezing cryopreservation of microencapsulated cells. Journal of Controlled Release , 281 pp. 119-138. 10.1016/j.jconrel.2018.05.016. Green open access

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Abstract

Over the past few decades, the use of cell microencapsulation technology has been promoted for a wide range of applications as sustained drug delivery systems or as cells containing biosystems for regenerative medicine. However, difficulty in their preservation and storage has limited their availability to healthcare centers. Because the preservation in cryogenic temperatures poses many biological and biophysical challenges and that the technology has not been well understood, the slow cooling cryopreservation, which is the most used technique worldwide, has not given full measure of its full potential application yet. This review will discuss the different steps that should be understood and taken into account to preserve microencapsulated cells by slow freezing in a successful and simple manner. Moreover, it will review the slow freezing preservation of alginate-based microencapsulated cells and discuss some recommendations that the research community may pursue to optimize the preservation of microencapsulated cells, enabling the therapy translate from bench to the clinic.

Type: Article
Title: Advances in the slow freezing cryopreservation of microencapsulated cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jconrel.2018.05.016
Publisher version: https://doi.org/10.1016/j.jconrel.2018.05.016
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cryoprotectant (CPA), dimethylsulfoxide (DMSO), slow freezing, drug delivery, cell microencapsulation, alginate
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10052556
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