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One-step selective wettability modification of PMMA microfluidic devices by using controllable gradient UV irradiation (CGUI)

Liu, Y; Liang, C; Liu, C; Li, X; Li, C; Duan, C; Li, J; (2018) One-step selective wettability modification of PMMA microfluidic devices by using controllable gradient UV irradiation (CGUI). Sensors and Actuators B: Chemical , 273 pp. 1508-1518. 10.1016/j.snb.2018.07.034. Green open access

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Abstract

Poly (methyl methacrylate) (PMMA) has become increasingly popular to fabricate microfluidic devices. In a microfluidic device, different functional areas usually require different wettability to achieve a better performance. However, most of the existing wettability modification methods have been applied to the whole PMMA surface making the device have minimum wettability difference. In this paper, a controllable gradient UV irradiation (CGUI) method was presented. In this method, a series of quartz plates sputtered with different thickness of Cu were arranged on top of the PMMA surface. By controlling the thickness of Cu film, the UV irradiation, which transmitted though the quartz plates onto the PMMA surface, can be adjusted making the modification performance able to be varied accordingly. The validation of the proposed CGUI was conducted through contact angle measurements. Our results showed that through 5 mins CGUI process, the contact angle for different parts of the PMMA surface can be varied from 45.48° to 77.41° continuously with a long-term stability of 60 days. To demonstrate this method, a fully integrated Point-of-Care Test (POCT) device was designed and fabricated for the detection of cardiac Troponin I achieving the lower detection limit of 85 pg/ml within 10 min.

Type: Article
Title: One-step selective wettability modification of PMMA microfluidic devices by using controllable gradient UV irradiation (CGUI)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.snb.2018.07.034
Publisher version: https://doi.org/10.1016/j.snb.2018.07.034
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: selective wettability modification, polymer, UV/ozone, microfluidic device
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10052295
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