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Senescence in chronic liver disease: Is the future in aging?

Arayinthan, AD; Alexander, GJM; (2016) Senescence in chronic liver disease: Is the future in aging? [Review]. Journal of Hepatology , 65 (4) pp. 825-834. 10.1016/j.jhep.2016.05.030. Green open access

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Abstract

Cellular senescence is a fundamental, complex mechanism with an important protective role present from embryogenesis to late life across all species. It limits the proliferative potential of damaged cells thus protecting against malignant change, but at the expense of substantial alterations to the microenvironment and tissue homeostasis, driving inflammation, fibrosis and paradoxically, malignant disease if the process is sustained. Cellular senescence has attracted considerable recent interest with recognition of pathways linking aging, malignancy and insulin resistance and the current focus on therapeutic interventions to extend health-span. There are major implications for hepatology in the field of fibrosis and cancer, where cellular senescence of hepatocytes, cholangiocytes, stellate cells and immune cells has been implicated in chronic liver disease progression. This review focuses on cellular senescence in chronic liver disease and explores therapeutic opportunities.

Type: Article
Title: Senescence in chronic liver disease: Is the future in aging?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhep.2016.05.030
Publisher version: http://doi.org/10.1016/j.jhep.2016.05.030
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cellular senescence, Hepatocyte senescence, Chronic liver disease, Liver fibrosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10052116
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