UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Optimal design for longitudinal studies to estimate pubertal height growth in individuals

Cole, TJ; (2018) Optimal design for longitudinal studies to estimate pubertal height growth in individuals. Annals of Human Biology , 45 (4) pp. 314-320. 10.1080/03014460.2018.1453948. Green open access

[img]
Preview
Text
Cole VoR20_02_2019_Optimal de.pdf - Published version

Download (4MB) | Preview

Abstract

BACKGROUND: The SITAR model expresses individual pubertal height growth in terms of mean size, peak height velocity (PHV) and age at PHV. AIM: To use SITAR to identify the optimal time interval between measurements to summarise individual pubertal height growth. SUBJECTS AND METHODS: Heights in 3172 boys aged 9-19 years from Christ's Hospital School measured on 128 679 occasions (a median of 42 heights per boy) were analysed using the SITAR (SuperImposition by Translation And Rotation) mixed effects growth curve model, which estimates a mean curve and three subject-specific random effects. Separate models were fitted to sub-sets of the data with measurement intervals of 2, 3, 4, 6, 12 and 24 months, and the different models were compared. RESULTS: The models for intervals 2-12 months gave effectively identical results for the residual standard deviation (0.8 cm), mean spline curve (6 degrees of freedom) and random effects (correlations >0.9), showing there is no benefit in measuring height more often than annually. The model for 2-year intervals fitted slightly less well, but needed just four-to-five measurements per individual. CONCLUSIONS: Height during puberty needs to be measured only annually and, with slightly lower precision, just four biennial measurements can be sufficient.

Type: Article
Title: Optimal design for longitudinal studies to estimate pubertal height growth in individuals
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/03014460.2018.1453948
Publisher version: https://doi.org/10.1080/03014460.2018.1453948
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Height, SITAR, age at peak velocity, puberty
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10051893
Downloads since deposit
39Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item