Goksan, S;
Hartley, C;
Hurley, SA;
Winkler, AM;
Duff, EP;
Jenkinson, M;
Rogers, R;
... Slater, R; + view all
(2017)
Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation.
Magnetic Resonance in Medicine
, 78
(2)
pp. 625-631.
10.1002/mrm.26455.
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Abstract
Purpose: Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI), is dependent on the echo time (TE) and the reversible spin–spin relaxation time constant ( urn:x-wiley:07403194:media:mrm26455:mrm26455-math-0001) that describes the decay of transverse magnetization. Use of the optimal TE during fMRI experiments allows maximal sensitivity to BOLD to be achieved. Reports that urn:x-wiley:07403194:media:mrm26455:mrm26455-math-0002 values are longer in infants (due to higher water concentrations and lower lipid content) have led to the use of longer TEs during infant fMRI experiments; however, the optimal TE has not been established. // Methods: In this study, acute experimental mildly noxious stimuli were applied to the heel in 12 term infants (mean gestational age = 40 weeks, mean postnatal age = 3 days); and the percentage change in BOLD activity was calculated across a range of TEs, from 30 to 70 ms, at 3 Tesla. In addition, urn:x-wiley:07403194:media:mrm26455:mrm26455-math-0003 maps of the whole brain were collected in seven infants. // Results: The maximal change in BOLD occurred at a TE of 52 ms, and the average urn:x-wiley:07403194:media:mrm26455:mrm26455-math-0004 across the whole brain was 99 ms. // Conclusion: A TE of approximately 50 ms is recommended for use in 3T fMRI investigations in term infants.
| Type: | Article |
|---|---|
| Title: | Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.26455 |
| Publisher version: | https://doi.org/10.1002/mrm.26455 |
| Language: | English |
| Additional information: | Copyright © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | BOLD; brain; echo time; imaging; T*2; infants; pain |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Culture, Communication and Media |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051842 |
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