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Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Bjorefeldt, A; Illes, S; Zetterberg, H; Hanse, E; (2018) Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies. Frontiers in Neural Circuits , 12 , Article 5. 10.3389/fncir.2018.00005. Green open access

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Abstract

The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits in vivo via volume transmission. Recent in vitro experimental work in brain slices and neuronal cultures has shown that human CSF indeed contains neuromodulators that strongly influence neuronal activity. Here we briefly summarize these new findings and discuss their potential relevance to neural circuits in health and disease.

Type: Article
Title: Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fncir.2018.00005
Publisher version: https://doi.org/10.3389/fncir.2018.00005
Language: English
Additional information: Copyright © 2018 Bjorefeldt, Illes, Zetterberg and Hanse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: cerebrospinal fluid, neuromodulation, neural circuit
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10051841
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