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Does presence of left ventricular contractile reserve improve response to cardiac resynchronization therapy? An updated meta-analysis

Papageorgiou, N; Providência, R; Lambiase, PD; Tousoulis, D; Lloyd, G; Bhattacharyya, S; (2018) Does presence of left ventricular contractile reserve improve response to cardiac resynchronization therapy? An updated meta-analysis. International Journal of Cardiology , 252 pp. 224-228. 10.1016/j.ijcard.2017.09.034. Green open access

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Abstract

BACKGROUND: Up to a third of patients undergoing cardiac resynchronization therapy (CRT) do not have a clinical or echocardiographic response. It is also unclear, whether contractile reserve (CR) could predict CRT response. This meta-analysis examines whether the presence of CR improves response to CRT and whether this is modulated by other clinical factors. METHODS: Search of PubMed/EMBASE/Cochrane databases for articles examining response to CRT stratified by the presence or not of CR. End-point classified as clinical or echocardiographic response. The analysis compared response to CRT (echocardiographic or clinical) between patients with or without CR. RESULTS: 824 patients in 12 studies were included. The presence of left ventricular CR was associated with a significant reduction in echocardiographic non-responders to CRT compared to patients without CR (OR: 0.16, 95% CI 0.08–0.33, p < 0.00001). The presence of left ventricular CR was associated with a significant reduction in clinical non-responders to CRT compared to patients without CR (OR: 0.23, 95% CI 0.14–0.37, p < 0.00001). Sensitivity analysis showed no difference in response when pooling studies using left ventricular ejection fraction (LVEF) or non-LVEF markers of CR. Meta-regression showed that CR was associated with lower rates of non-responders and this was more pronounced in patients with a narrower mean QRS complex. CONCLUSIONS: Identification of CR is associated with improved response to CRT. Importantly, QRS width is a potential moderator variable which can explain part of the heterogeneity in echo response. The combination of CR and QRS width may modulate the response to CRT

Type: Article
Title: Does presence of left ventricular contractile reserve improve response to cardiac resynchronization therapy? An updated meta-analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijcard.2017.09.034
Publisher version: https://doi.org/10.1016/j.ijcard.2017.09.034
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Contractile reserve, Cardiac resynchronization therapy, Heart failure
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: https://discovery.ucl.ac.uk/id/eprint/10051781
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