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Polysomnography in Bolivian Children Native to High Altitude Compared to Children Native to Low Altitude

Hill, CM; Carroll, A; Dimitriou, D; Gavlak, J; Heathcote, K; L'Esperance, V; Baya, A; ... Bucks, RS; + view all (2016) Polysomnography in Bolivian Children Native to High Altitude Compared to Children Native to Low Altitude. Sleep , 39 (12) pp. 2149-2155. 10.5665/sleep.6316. Green open access

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Abstract

Study Objectives: To compare polysomnographic parameters in high altitude (HA) native Andean children with low altitude (LA) native peers in order to explain the nocturnal oxyhemoglobin saturation (SpO2) instability reported in HA native children and to study the effect on sleep quality. // Methods: Ninety-eight healthy children aged 7–10 y and 13–16 y were recruited at LA (500 m) or HA (3,650 m) above sea level. Physical examination was undertaken and genetic ancestry determined from salivary DNA to determine proportion of European ancestry, a risk factor for poor HA adaptation. Attended polysomnography was carried out over 1 night for 58 children at their resident location. // Results: Of 98 children recruited, 85 met inclusion criteria, 58 of 85 (68.2%) completed polysomnography, of which 56 were adequate for analysis: 30 at LA (17 male) and 26 at HA (16 male). There were no altitude differences in genetic ancestry, but a high proportion of European admixture (median 50.6% LA; 44.0% HA). SpO2 was less stable at HA with mean 3% and 4% oxygen desaturation indices greater (both P < 0.001) than at LA. This was not explained by periodic breathing. However, more obstructive hypopnea was observed at HA (P < 0.001), along with a trend toward more central apnea (P = 0.053); neither was explained by clinical findings. There was no difference in sleep quality between altitudes. // Conclusions: HA native Andean children have more respiratory events when scoring relies on SpO2 desaturation due to inherent SpO2 instability. Use of American Academy of Sleep Medicine scoring criteria may yield false-positive results for obstructive sleep-disordered breathing at HA.

Type: Article
Title: Polysomnography in Bolivian Children Native to High Altitude Compared to Children Native to Low Altitude
Open access status: An open access version is available from UCL Discovery
DOI: 10.5665/sleep.6316
Publisher version: https://doi.org/10.5665/sleep.6316
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: adaptation, apnea, hypopnea, high altitude, hypoxia, polysomnography, sleep-disordered breathing
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Psychology and Human Development
URI: https://discovery.ucl.ac.uk/id/eprint/10051714
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