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Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

Betts, MJ; Ehrenberg, AJ; Hämmerer, D; Düzel, E; (2018) Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. Frontiers in Neuroscience , 12 , Article 401. 10.3389/fnins.2018.00401. Green open access

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Abstract

A commentary on: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice by Chalermpalanupap, T., Schroeder, J. P., Rorabaugh, J. M., Liles, L. C., Lah, J. J., Levey, A. I., et al. (2018). J. Neurosci. 38, 74–92. doi: 10.1523/JNEUROSCI.1483-17.2017. Alzheimer's disease (AD) is characterized by progressive neuron loss as well as the accumulation of neurofibrillary tangles, otherwise referred to as tau pathology, and β-amyloid plaques. Second to neuron loss, tau pathology is the best predictor of cognitive decline in AD. Recently, tau pathology onset in the locus coeruleus (LC) has been shown to consistently precede cortical tau pathology and increase in severity along Braak staging.

Type: Article
Title: Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnins.2018.00401
Publisher version: https://doi.org/10.3389/fnins.2018.00401
Language: English
Additional information: © 2018 Betts, Ehrenberg, Hämmerer and Düzel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Keywords: locus coeruleus, norepinephrine, hippocampus, tauopathy, learning and memory, neuropathology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10051501
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