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Development of random and ordered composite fiber hybrid technologies for controlled release functions

Wang, B; Ahmad, Z; Huang, J; Li, J-S; Chang, M-W; (2018) Development of random and ordered composite fiber hybrid technologies for controlled release functions. Chemical Engineering Journal , 343 pp. 379-389. 10.1016/j.cej.2018.03.021. (In press). Green open access

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Abstract

Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.

Type: Article
Title: Development of random and ordered composite fiber hybrid technologies for controlled release functions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cej.2018.03.021
Publisher version: http://dx.doi.org/10.1016/j.cej.2018.03.021
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Technology, Engineering, Environmental, Engineering, Chemical, Engineering, Electrospinning, EHD continuous jetting, Rapid drug release, Sustained drug release, Hybrid system, DRUG-DELIVERY SYSTEMS, TETRACYCLINE HYDROCHLORIDE, MECHANICAL-PROPERTIES, SILVER NANOPARTICLES, FABRICATION, NANOFIBERS, POLYURETHANE, EQUATION, CARRIERS, SCAFFOLD
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10051419
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