Engelborghs, S;
Niemantsverdriet, E;
Struyfs, H;
Blennow, K;
Brouns, R;
Comabella, M;
Dujmovic, I;
... Teunissen, CE; + view all
(2017)
Consensus guidelines for lumbar puncture in patients with neurological diseases.
Alzheimers Dement (Amst)
, 8
pp. 111-126.
10.1016/j.dadm.2017.04.007.
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Abstract
INTRODUCTION: Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. METHODS: We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). RESULTS: Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. DISCUSSION: When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.
| Type: | Article |
|---|---|
| Title: | Consensus guidelines for lumbar puncture in patients with neurological diseases. |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.dadm.2017.04.007 |
| Publisher version: | https://doi.org/10.1016/j.dadm.2017.04.007 |
| Language: | English |
| Additional information: | ©� 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Back pain, Cerebrospinal fluid, Consensus guidelines, Evidence-based guidelines, Headache, Lumbar puncture, Post-LP complications |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051235 |
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