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Lung Organoids and Their Use To Study Cell-Cell Interaction

Nikolić, MZ; Rawlins, EL; (2017) Lung Organoids and Their Use To Study Cell-Cell Interaction. Current Pathobiology Reports , 5 (2) pp. 223-231. 10.1007/s40139-017-0137-7. Green open access

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Abstract

The use of co-culture organoid systems has facilitated the in vitro cultivation of previously inaccessible stem cell populations, providing a novel method for dissecting the molecular requirements of these cell-cell interactions. Future technology development will allow the growth of epithelial-only organoids in more defined media and also the introduction of specific non-epithelial cells for the study of cell interactions. These developments will require an improved understanding of the epithelial and non-epithelial cell types present in the lung and their lineage relationships.

Type: Article
Title: Lung Organoids and Their Use To Study Cell-Cell Interaction
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40139-017-0137-7
Publisher version: http://doi.org/10.1007/s40139-017-0137-7
Language: English
Additional information: Copyright © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Organoids, Lung progenitors, Mouse lung, Human lung, iPSCs
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10051183
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