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Liquorice, Liddle, Bartter or Gitelman—how to differentiate?

Mumford, E; Unwin, RJ; Walsh, SB; (2018) Liquorice, Liddle, Bartter or Gitelman—how to differentiate? Nephrology Dialysis Transplantation , 34 (1) pp. 38-39. 10.1093/ndt/gfy199. Green open access

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Abstract

Hypokalaemia with alkalosis can suggest excess aldosterone. Aldosterone stimulates the collecting duct mineralocorticoid receptor (MR) to upregulate the epithelial sodium channel (ENaC) and stimulate electrogenic sodium reabsorption, with secretion of potassium and protons. Gitelman, Bartter and Liddle syndrome, and liquorice ingestion all cause hypokalaemic alkalosis. This mini-review outlines the pathophysiology of these conditions as well as how to differentiate them.

Type: Article
Title: Liquorice, Liddle, Bartter or Gitelman—how to differentiate?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ndt/gfy199
Publisher version: https://doi.org/10.1093/ndt/gfy199
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: hypokalaemia, gitelman, bartter, liddle, liquorice
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10051168
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