UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The evolving role of endoscopy in the diagnosis of premalignant gastric lesions [version 1; referees: 4 approved]

Jansen, M; Waddingham, W; Graham, D; Banks, M; (2018) The evolving role of endoscopy in the diagnosis of premalignant gastric lesions [version 1; referees: 4 approved]. [Review]. F1000Research , 7 , Article 715. 10.12688/f1000research.12087.1. Green open access

[thumbnail of 811e8183-49c1-45f9-8c9c-e588f0e39024_12087_-_Marnix_Jansen.pdf]
Preview
Text
811e8183-49c1-45f9-8c9c-e588f0e39024_12087_-_Marnix_Jansen.pdf - Published Version

Download (3MB) | Preview

Abstract

Gastric adenocarcinoma is a disease that is often detected late, at a stage when curative treatment is unachievable. This must be addressed through changes in our approach to the identification of patients at increased risk by improving the detection and risk assessment of premalignant changes in the stomach, including chronic atrophic gastritis and intestinal metaplasia. Current guidelines recommend utilising random biopsies in a pathology-led approach in order to stage the extent and severity of gastritis and intestinal metaplasia. This random method is poorly reproducible and prone to sampling error and fails to acknowledge recent advances in our understanding of the progression to gastric cancer as a non-linear, branching evolutionary model. Data suggest that recent advances in endoscopic imaging modalities, such as narrow band imaging, can achieve a high degree of accuracy in the stomach for the diagnosis of these premalignant changes. In this review, we outline recent data to support a paradigm shift towards an endoscopy-led approach to diagnosis and staging of premalignant changes in the stomach. High-quality endoscopic interrogation of the chronically inflamed stomach mucosa, supported by targeted biopsies, will lead to more accurate risk assessment, with reduced rates of under or missed diagnoses.

Type: Article
Title: The evolving role of endoscopy in the diagnosis of premalignant gastric lesions [version 1; referees: 4 approved]
Open access status: An open access version is available from UCL Discovery
DOI: 10.12688/f1000research.12087.1
Publisher version: http://dx.doi.org/10.12688/f1000research.12087.1
Language: English
Additional information: © 2018 Waddingham W et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original data is properly cited.
Keywords: Gastric cancer, endoscopy, premalignant lesions
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10051141
Downloads since deposit
31Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item