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Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex

Khan, AG; Poort, J; Chadwick, A; Blot, A; Sahani, M; Mrsic-Flogel, TD; Hofer, SB; (2018) Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex. Nature Neuroscience , 21 (6) pp. 851-859. 10.1038/s41593-018-0143-z. Green open access

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Abstract

How learning enhances neural representations for behaviorally relevant stimuli via activity changes of cortical cell types remains unclear. We simultaneously imaged responses of pyramidal cells (PYR) along with parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptide (VIP) inhibitory interneurons in primary visual cortex while mice learned to discriminate visual patterns. Learning increased selectivity for task-relevant stimuli of PYR, PV and SOM subsets but not VIP cells. Strikingly, PV neurons became as selective as PYR cells, and their functional interactions reorganized, leading to the emergence of stimulus-selective PYR–PV ensembles. Conversely, SOM activity became strongly decorrelated from the network, and PYR–SOM coupling before learning predicted selectivity increases in individual PYR cells. Thus, learning differentially shapes the activity and interactions of multiple cell classes: while SOM inhibition may gate selectivity changes, PV interneurons become recruited into stimulus-specific ensembles and provide more selective inhibition as the network becomes better at discriminating behaviorally relevant stimuli.

Type: Article
Title: Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-018-0143-z
Publisher version: http://doi.org/10.1038/s41593-018-0143-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10051105
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