Xu, L;
Zhu, B;
Huang, Y;
Yang, Z;
Sun, J;
Xu, Y;
Zheng, J;
... Wu, N; + view all
(2018)
Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients.
Mediators of Inflammation
, 2018
, Article 5201652. 10.1155/2018/5201652.
![[thumbnail of 5201652.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
5201652.pdf - Published Version Download (1MB) |
Abstract
BACKGROUND: Butyrylcholinesterase (BChE) is synthesized mainly in the liver and an important marker in many infectious/inflammatory diseases, but its role in acquired immunodeficiency syndrome (AIDS) patients is not clear. We wished to ascertain if BChE level is associated with the progression/prognosis of AIDS patients. METHODS: BChE levels (in U/L) were measured in 505 patients; <4500 was defined as “low” and ≥4500 as “normal.” Associations between BChE level and CD4 count, WHO stage, body mass index (BMI), C-reactive protein (CRP) level, and duration of hospitalization were assessed. Kaplan–Meier curves and Cox proportional hazards model were used to assess associations between low BChE levels and mortality, after adjustment for age, CD4 count, WHO stage, and laboratory parameters. RESULTS: A total of 129 patients (25.5%) had a lower BChE level. BChE was closely associated with CD4 count, WHO stage, CRP level, and BMI (all P < 0 001). Eighty-four patients (16.6%) died in the first year of follow-up. One-year survival was 64.5 ± 4.5% for patients with low BChE and 87.6 ± 1.8% for those with normal BChE (log-rank, P < 0 001). After adjustment for sex, age, BMI, WHO stage, and CD4 count, as well as serum levels of hemoglobin, sodium, and albumin, the hazard ratio was 1.8 (95% confidence interval, 1.0–3.2) for patients with a low BChE compared with those with a normal BChE (P = 0 035). CONCLUSION: BChE level is associated with HIV/AIDS severity and is an independent risk factor for increased mortality in AIDS patients.
| Type: | Article |
|---|---|
| Title: | Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1155/2018/5201652 |
| Publisher version: | http://dx.doi.org/10.1155/2018/5201652 |
| Language: | English |
| Additional information: | © 2018 Lijun Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, Immunology, GRADE SYSTEMIC INFLAMMATION, HEPATIC STELLATE CELLS, HIV-INFECTED PATIENTS, ANTIRETROVIRAL THERAPY, LIVER-DISEASE, IMMUNODEFICIENCY, ACETYLCHOLINESTERASE, PSEUDOCHOLINESTERASE, NUTRITION, PROTEIN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051069 |
Archive Staff Only
 |
View Item |
