UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits

Howe, LJ; Erzurumluoglu, AM; Davey Smith, G; Rodriguez, S; Stergiakouli, E; (2017) Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits. Sci Rep , 7 , Article 11655. 10.1038/s41598-017-10871-4. Green open access

[thumbnail of Published article]
Preview
Text (Published article)
Howe_Y Chromosome.pdf - Published Version

Download (1MB) | Preview
[thumbnail of Supplementary information]
Preview
Text (Supplementary information)
41598_2017_10871_MOESM1_ESM.pdf

Download (344kB) | Preview

Abstract

Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.

Type: Article
Title: Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-017-10871-4
Publisher version: https://doi.org/10.1038/s41598-017-10871-4
Language: English
Additional information: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/10050943
Downloads since deposit
107Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item