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The Developmental Origin of Heart Size and Shape Differences in Astyanax mexicanus populations

Tang, JLY; Guo, Y; Stockdale, WT; Rana, K; Killen, A; Mommersteeg, MTM; Yamamoto, Y; (2018) The Developmental Origin of Heart Size and Shape Differences in Astyanax mexicanus populations. Developmental Biology 10.1016/j.ydbio.2018.06.009. (In press). Green open access

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Abstract

Regulation of heart size and shape is one of the least understood processes in developmental biology. We have for the first time analysed the hearts of Astyanax mexicanus and identified several differences in heart morphology between the surface (epigean morph) and cave-dwelling (troglomorph) morphs. Examination of the adult revealed that the troglomorph possesses a smaller heart with a rounder ventricle in comparison to the epigean morph. The size differences identified appear to arise early in development, as early as 24 hours post-fertilisation (hpf), while shape differences begin to appear at 2 days post-fertilisation. The heart of the first-generation cross between the cave-dwelling and river-dwelling morph shows uncoupling of different phenotypes observed in the parental populations and indicates that the cardiac differences have become embedded in the genome during evolution. The differences in heart morphology are accompanied by functional changes between the two morphs, with the cave-dwelling morph exhibiting a slower heart rate than the river-dwelling morph. The identification of morphological and functional differences in the A. mexicanus heart could allow us to gain more insight into how such parameters are regulated during cardiac development, with potential relevance to cardiac pathologies in humans.

Type: Article
Title: The Developmental Origin of Heart Size and Shape Differences in Astyanax mexicanus populations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ydbio.2018.06.009
Publisher version: https://doi.org/10.1016/j.ydbio.2018.06.009
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
Keywords: Heart development, Heart morphology, Organ Size, Astyanax mexicanus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10050869
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