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Clinical Implications of Genomic Discoveries in Lung Cancer

Swanton, C; Govindan, R; (2016) Clinical Implications of Genomic Discoveries in Lung Cancer. New England Journal of Medicine , 374 (19) pp. 1864-1873. 10.1056/NEJMra1504688. Green open access

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Abstract

Lung cancer is one of the leading causes of death globally.1 Tobacco smoking causes nearly 90% of lung cancers. The major histologic types of lung cancer include adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell neuroendocrine carcinoma, and pulmonary carcinoid tumors.2 Although some molecular alterations are shared among various histologic subtypes, the majority of genomic alterations remain distinct. In this review, we discuss recent studies of large-scale genomic analyses of the three most common histologic types of lung cancer — adenocarcinoma, squamous-cell carcinoma, and small-cell carcinoma — and their implications for the management of this disease.

Type: Article
Title: Clinical Implications of Genomic Discoveries in Lung Cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1056/NEJMra1504688
Publisher version: http://dx.doi.org/10.1056/NEJMra1504688
Language: English
Additional information: This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10050836
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