Swanton, C;
Govindan, R;
(2016)
Clinical Implications of Genomic Discoveries in Lung Cancer.
New England Journal of Medicine
, 374
(19)
pp. 1864-1873.
10.1056/NEJMra1504688.
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Abstract
Lung cancer is one of the leading causes of death globally.1 Tobacco smoking causes nearly 90% of lung cancers. The major histologic types of lung cancer include adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell neuroendocrine carcinoma, and pulmonary carcinoid tumors.2 Although some molecular alterations are shared among various histologic subtypes, the majority of genomic alterations remain distinct. In this review, we discuss recent studies of large-scale genomic analyses of the three most common histologic types of lung cancer — adenocarcinoma, squamous-cell carcinoma, and small-cell carcinoma — and their implications for the management of this disease.
| Type: | Article |
|---|---|
| Title: | Clinical Implications of Genomic Discoveries in Lung Cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1056/NEJMra1504688 |
| Publisher version: | http://dx.doi.org/10.1056/NEJMra1504688 |
| Language: | English |
| Additional information: | This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050836 |
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