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Overview and Critical Appraisal of Arterial Spin Labelling Technique in Brain Perfusion Imaging

Alsaedi, A; Thomas, D; Bisdas, S; Golay, X; (2018) Overview and Critical Appraisal of Arterial Spin Labelling Technique in Brain Perfusion Imaging. Contrast Media and Molecular Imaging , Article ID 5360375. 10.1155/2018/5360375. Green open access

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Abstract

Arterial spin labelling (ASL) allows absolute quantification of CBF via a diffusible intrinsic tracer (magnetically labelled blood water) that disperses from the vascular system into neighbouring tissue. Thus, it can provide absolute CBF quantification, which eliminates the need for the contrast agent, and can be performed repeatedly. This review will focus on the common ASL acquisition techniques (continuous, pulsed, and pseudocontinuous ASL) and how ASL image quality might be affected by intrinsic factors that may bias the CBF measurements. We also provide suggestions to mitigate these risks, model appropriately the acquired signal, increase the image quality, and hence estimate the reliability of the CBF, which consists an important noninvasive biomarker. Emerging methodologies for extraction of new ASL-based biomarkers, such as arterial arrival time (AAT) and arterial blood volume (aBV), will be also briefly discussed.

Type: Article
Title: Overview and Critical Appraisal of Arterial Spin Labelling Technique in Brain Perfusion Imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2018/5360375
Publisher version: https://doi.org/10.1155/2018/5360375
Language: English
Additional information: Copyright © 2018 Amirah Alsaedi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Cerebral-Blood-Flow, Transit-Time, Magnetization-Transfer, Multislice Perfusion, Adiabatic Inversion, Rat-Brain, Quipss II, Tumors, Mri, Angiogenesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10050808
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