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Diagnosed depression and sociodemographic factors as predictors of mortality in patients with dementia

Lewis, G; Werbeloff, N; Hayes, JF; Howard, R; Osborn, DPJ; (2018) Diagnosed depression and sociodemographic factors as predictors of mortality in patients with dementia. The British Journal of Psychiatry , 213 (2) pp. 471-476. 10.1192/bjp.2018.86. Green open access

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Abstract

BACKGROUND: Potentially modifiable risk factors for developing dementia have been identified. However, risk factors for increased mortality in patients with diagnosed dementia are not well understood. Identifying factors that influence prognosis would help clinicians plan care and address unmet needs. AIMS: To investigate diagnosed depression and sociodemographic factors as predictors of mortality in patients with dementia in UK secondary clinical care services. METHOD: We conducted a cohort study of patients with a dementia diagnosis in an electronic health records database in a UK National Health Service mental health trust. RESULTS: In 3374 patients with 10 856 person-years of follow-up, comorbid depression was not associated with mortality (adjusted hazard ratio 0.94; 95% CI 0.71-1.24). Single patients had higher mortality than those who were married (adjusted hazard ratio 1.25; 95% CI 1.03-1.50). Patients of Asian ethnicity had lower mortality rates than White British patients (adjusted hazard ratio 0.50; 95% CI 0.34-0.73). CONCLUSIONS: Clinically diagnosed depression does not increase mortality in patients with dementia. Patients who are single are a potential high-mortality risk group. Lower mortality rates in Asian patients with dementia that have been reported in the USA also apply in the UK. DECLARATION OF INTERESTS: None.

Type: Article
Title: Diagnosed depression and sociodemographic factors as predictors of mortality in patients with dementia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.2018.86
Publisher version: https://doi.org/10.1192/bjp.2018.86
Language: English
Additional information: Copyright © The Royal College of Psychiatrists 2018. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/ 4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10050732
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