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The effect of antidiabetic medications on non-alcoholic fatty liver disease (NAFLD)

Iogna Prat, L; Tsochatzis, EA; (2018) The effect of antidiabetic medications on non-alcoholic fatty liver disease (NAFLD). Hormones , 17 (2) pp. 219-229. 10.1007/s42000-018-0021-9. Green open access

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is prevalent in more than 50% of patients with type II diabetes. At present, there is no approved therapy for NASH. Until now, the only proven effective interventions in improving biochemical and histological features of NASH, including fibrosis, are weight loss and physical activity even without weight loss. Because of the common epidemiological and pathophysiological features between NAFLD and T2DM, many antidiabetics drugs have been tested in patients with NAFLD over the years. Among these, pioglitazone and liraglutide seem to improve some histological features of NASH but have no clear effect on fibrosis. Metformin has been largely studied in the past years without convincing evidence of improving NAFLD. Data on other compounds such as DDP-4 and SGLT-2 inhibitors are limited. The rational and results of such studies are discussed in the present review.

Type: Article
Title: The effect of antidiabetic medications on non-alcoholic fatty liver disease (NAFLD)
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s42000-018-0021-9
Publisher version: http://dx.doi.org/10.1007/s42000-018-0021-9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: HCC, Liraglutide, Metformin, Pioglitazone, Steatohepatitis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10050696
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