Raja, J;
Denton, CP;
(2016)
Emerging evidence-based therapies for systemic sclerosis.
Indian Journal of Rheumatology
, 11
(3)
pp. 153-163.
10.4103/0973-3698.187423.
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Abstract
Systemic sclerosis (SSc) (scleroderma) is an uncommon multisystem connective tissue disease with high unmet need and mortality. There has been an improvement in overall outcome and survival over the past three decades, but it still has the highest mortality among any of the autoimmune rheumatic diseases. Progress in its management has come through more organized assessment and treatment together with the emergence of therapies that can target specific complications of the disease such as renal crisis and pulmonary arterial hypertension. In addition, there is a growing understanding of pathogenesis that allows more targeted approaches to therapy to be explored in clinical trials. In this review, several aspects of SSc management including the more targeted therapies including strategies to block specific pathways or mediators have been discussed.
| Type: | Article |
|---|---|
| Title: | Emerging evidence-based therapies for systemic sclerosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4103/0973-3698.187423 |
| Publisher version: | https://doi.org/10.4103/0973-3698.187423 |
| Language: | English |
| Additional information: | Copyright © 2016 Indian Journal of Rheumatology | Published by Wolters Kluwer - Medknow. This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License (https://creativecommons.org/licenses/by-nc-sa/3.0/), which allows others to remix, tweak, and build upon the work non‑commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
| Keywords: | Immunosuppressants, scleroderma, systemic sclerosis, therapies, treatments |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050656 |
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