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Senescence drives non-cell autonomous tumorigenesis in the pituitary gland

Gonzalez-Meljem, JM; Martinez-Barbera, JP; (2018) Senescence drives non-cell autonomous tumorigenesis in the pituitary gland. Molecular & Cellular Oncology , 5 (3) , Article e1435180. 10.1080/23723556.2018.1435180. Green open access

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Abstract

Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors. Here we discuss how cellular senescence and its secretory phenotype can be involved in the widely unexplored phenomenon of paracrine tumorigenesis.

Type: Article
Title: Senescence drives non-cell autonomous tumorigenesis in the pituitary gland
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/23723556.2018.1435180
Publisher version: https://doi.org/10.1080/23723556.2018.1435180
Language: English
Additional information: Copyright © 2018 Jose Mario Gonzalez-Meljem, and Juan Pedro Martinez-Barbera. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
Keywords: SASP, adamantinomatous craniopharyngioma, pituitary, senescence, stem cells, β-catenin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10050538
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