Gonzalez-Meljem, JM;
Martinez-Barbera, JP;
(2018)
Senescence drives non-cell autonomous tumorigenesis in the pituitary gland.
Molecular & Cellular Oncology
, 5
(3)
, Article e1435180. 10.1080/23723556.2018.1435180.
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Abstract
Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors. Here we discuss how cellular senescence and its secretory phenotype can be involved in the widely unexplored phenomenon of paracrine tumorigenesis.
| Type: | Article |
|---|---|
| Title: | Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/23723556.2018.1435180 |
| Publisher version: | https://doi.org/10.1080/23723556.2018.1435180 |
| Language: | English |
| Additional information: | Copyright © 2018 Jose Mario Gonzalez-Meljem, and Juan Pedro Martinez-Barbera. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| Keywords: | SASP, adamantinomatous craniopharyngioma, pituitary, senescence, stem cells, β-catenin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050538 |
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