Brown, DA;
(2018)
Norman Bowery's discoveries about extrasynaptic and asynaptic GABA systems and their significance.
Neuropharmacology
, 136
(A)
pp. 3-9.
10.1016/j.neuropharm.2017.11.006.
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Abstract
Before discovering the GABA-B receptor, Norman Bowery completed a series of studies on an extrasynaptic or asynaptic “GABA system” in the rat superior cervical sympathetic ganglion. First, he discovered an uptake system for GABA in neuroglial cells in the ganglia and in peripheral nerves, with a different substrate specificity than that in neurons. Second, he showed that accumulated GABA in sympathetic glial cells was metabolized to succinate by a transaminase enzyme. Third, he provided detailed structure-activity information about compounds activating an extrasynaptic GABA-A receptor on neurons in the rat sympathetic ganglion. Fourth, he showed that some amino acid substrates for the neuroglial transporter could indirectly stimulate neurons by releasing GABA from adjacent glial cells, and that GABA could also be released from neuroglial cells by membrane depolarization. In this review, these discoveries are briefly described and updated and some of their implications assessed.
| Type: | Article |
|---|---|
| Title: | Norman Bowery's discoveries about extrasynaptic and asynaptic GABA systems and their significance |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuropharm.2017.11.006 |
| Publisher version: | https://doi.org/10.1016/j.neuropharm.2017.11.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Sympathetic ganglion, Sensory ganglia, Neuroglial cells, GABA uptake, GABA release, GABA-A receptor, GABA depolarization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050311 |
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