Ossowski, P;
Curatolo, A;
Sampson, DD;
Munro, PRT;
(2018)
Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation.
Biomedical Optics Express
, 9
(7)
pp. 3122-3136.
10.1364/BOE.9.003122.
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Abstract
Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that an optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.
| Type: | Article |
|---|---|
| Title: | Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.9.003122 |
| Publisher version: | https://doi.org/10.1364/BOE.9.003122 |
| Language: | English |
| Additional information: | Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/). Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050239 |
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