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Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with Ga-68-PSMA, radiolabelled choline and Ga-68-DOTATATE

Haroon, A; Afaq, A; Nuthakki, S; Freeman, A; Biassoni, L; Fanti, S; Beheshti, M; ... Bomanji, J; + view all (2018) Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with Ga-68-PSMA, radiolabelled choline and Ga-68-DOTATATE. [Review]. Nuclear Medicine Communications , 39 (3) pp. 196-204. 10.1097/MNM.0000000000000797. Green open access

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Abstract

The objective of this study was to highlight the role of multimodality imaging and present the differential diagnosis of abnormal tracer accumulation in the prostate and periprostatic tissue. Our departments have performed molecular imaging of the prostate utilizing PET-CT and PET-MRI with a range of biomarkers including F-FDG, radiolabelled choline, Ga-DOTATATE PET-CT and Ga-PSMA images. We retrospectively reviewed the varying appearances of the prostate gland in different diseases and incidental findings in periprostatic region. The differential diagnosis of pathologies related to prostate and periprostatic tissue on multimodality imaging includes malakoplakia, rhabdomyosarcoma, lymphoma, prostate cancer, neuroendocrine tumours, uchida changes, rectoprostatic fistula, synchronous malignancies, lymphocoele and schwanoma. There exists a wide differential for abnormal tracer accumulation in the prostate gland. As a radiologist and nuclear medicine physician, it is important to be aware of range of prostatic and periprostatic pathologies.

Type: Article
Title: Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with Ga-68-PSMA, radiolabelled choline and Ga-68-DOTATATE
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MNM.0000000000000797
Publisher version: https://insights.ovid.com/pubmed?pmid=29384832
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: choline, 68Ga-DOTATATE, 68Ga-PSMA, PET/CT, PET/MRI, prostate
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School
URI: https://discovery.ucl.ac.uk/id/eprint/10050186
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