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Joining the dots: protein-RNA interactions mediating local mRNA translation in neurons

Gallagher, C; Ramos, A; (2018) Joining the dots: protein-RNA interactions mediating local mRNA translation in neurons. FEBS Letters , 592 (17) pp. 2932-2947. 10.1002/1873-3468.13121. Green open access

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Abstract

Establishing and maintaining the complex network of connections required for neuronal communication requires the transport and in situ translation of large groups of mRNAs to create local proteomes. In this Review, we discuss the regulation of local mRNA translation in neurons and the RNA‐binding proteins that recognise RNA zipcode elements and connect the mRNAs to the cellular transport networks, as well as regulate their translation control. mRNA recognition by the regulatory proteins is mediated by the combinatorial action of multiple RNA binding domains. This increases the specificity and affinity of the interaction, while allowing the protein to recognise a diverse set of targets and mediate a range of mechanisms for translational regulation. The structural and molecular understanding of the interactions can be used together with novel microscopy and transcriptome‐wide data to build a mechanistic framework for the regulation of local mRNA translation.

Type: Article
Title: Joining the dots: protein-RNA interactions mediating local mRNA translation in neurons
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/1873-3468.13121
Publisher version: https://doi.org/10.1002/1873-3468.13121
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10050135
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