Alles, E;
Noimark, S;
Maneas, E;
Zhang, E;
Parkin, I;
Beard, P;
Desjardins, A;
(2018)
Video-Rate All-Optical Ultrasound Imaging.
Biomedical Optics Express
, 9
(8)
pp. 3481-3494.
10.1364/BOE.9.003481.
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Abstract
All-optical ultrasound imaging, where ultrasound is generated and detected using light, has recently been demonstrated as a viable modality that is inherently insensitive to electromagnetic interference and exhibits wide bandwidths. High-quality 2D and 3D all-optical ultrasound images of tissues have previously been presented; however, to date, long acquisition times (ranging from minutes to hours) have hindered clinical application. Here, we present the first all-optical ultrasound imaging system capable of video-rate, real-time two-dimensional imaging of biological tissue. This was achieved using a spatially extended nano-composite optical ultrasound generator, a highly sensitive fibre-optic acoustic receiver, and eccentric illumination resulting in an acoustic source exhibiting optimal directivity. This source was scanned across a one-dimensional source aperture using a fast galvo mirror, thus enabling the dynamic synthesis of source arrays comprising spatially overlapping sources at non-uniform source separation distances. The resulting system achieved a sustained frame rate of 15 Hz, a dynamic range of 30 dB, a penetration depth of at least 6 mm, a resolution of 75 µm (axial) by 100 µm (lateral), and enabled the dynamics of a pulsating ex vivo carotid artery to be captured.
| Type: | Article |
|---|---|
| Title: | Video-Rate All-Optical Ultrasound Imaging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.9.003481 |
| Publisher version: | https://doi.org/10.1364/BOE.9.003481 |
| Language: | English |
| Additional information: | Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/). Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050047 |
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