Peters, MJ;
Jones, GA;
Eaton, S;
Wiley, D;
Ray, S;
(2018)
Risks and benefits of oxygen therapy.
Journal of Inherited Metabolic Disease
, 41
(5)
pp. 757-759.
10.1007/s10545-018-0208-x.
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Abstract
Mootha and Chinnery review the risks and benefits of oxygen administration in mitochondrial disease. They highlight probable harm from hyperoxia and possible benefit from hypoxia. At first sight this is counter-intuitive. It seems improbable that reducing the availability of a substrate that enables high-energy phosphate production via oxidative phosphorylation would be of benefit. But recent clinical data beyond the field of inherited metabolic disease support this approach.
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