van Leeuwen, EM;
Emri, E;
Merle, BMJ;
Colijn, JM;
Kersten, E;
Cougnard-Gregoire, A;
Dammeier, S;
... Lengyel, I; + view all
(2018)
A new perspective on lipid research in age-related macular degeneration.
Progress in Retinal and Eye Research
, 67
pp. 56-86.
10.1016/j.preteyeres.2018.04.006.
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Abstract
There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.
| Type: | Article |
|---|---|
| Title: | A new perspective on lipid research in age-related macular degeneration |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.preteyeres.2018.04.006 |
| Publisher version: | https://doi.org/10.1016/j.preteyeres.2018.04.006 |
| Language: | English |
| Additional information: | © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode). |
| Keywords: | Age-related macular degeneration (AMD), High-density lipoprotein cholesterol (HDL-C), Dietary lipids, Circulating lipoproteins, Retinal lipids, Genetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10049644 |
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