Hamer, M;
Sharma, N;
Batty, GD;
(2018)
Association of objectively measured physical activity with brain structure: UK Biobank study.
Journal of Internal Medicine
, 284
(4)
pp. 439-443.
10.1111/joim.12772.
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Abstract
BACKGROUND: Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region. METHODS: We used data from UK Biobank (n = 5272; aged 55.4 ± 7.5 years; 45.6% men) collected through 2013–2016. Participants wore the Axivity AX3 wrist‐worn triaxial accelerometer for 7 days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain. RESULTS: There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 years old). We also observed associations of physical activity with both left (B = 0.52, 95% CI, 0.01, 1.03; P = 0.046) and right hippocampal volume (B = 0.59, 95% CI, 0.08, 1.10; P = 0.024) in covariate‐adjusted models. CONCLUSION: In summary, physical activity may play a role in the prevention of neurodegenerative diseases.
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