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Functional assessment of coronary artery disease by cardiac computed tomography

Treibel, TA; Rossi, A; Pugliese, F; Davies, LC; (2017) Functional assessment of coronary artery disease by cardiac computed tomography. Expert Review of Cardiovascular Therapy , 15 (9) pp. 657-665. 10.1080/14779072.2017.1359087. Green open access

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Abstract

INTRODUCTION: Rapid technological advances in computed tomography (CT) have allowed CT coronary angiography (CTCA) to be delivered at low radiation dose and high diagnostic accuracy. Due to its high negative predictive value for coronary artery disease, it has become a gatekeeper for the assessment of patients with chest pain of recent onset. Second line functional assessment of a detected coronary stenosis relies mostly on other imaging modalities. Functional assessment of coronary artery disease by CT is therefore an attractive addition to CTCA. AREAS COVERED: This review will discuss the current evidence base and future development for CT perfusion imaging. Furthermore, this review will discuss CT-derived fractional flow reserve and CT coronary plaque characteristics as alternative approaches for functional evaluation of coronary artery disease. Finally, combining coronary anatomy and functional assessment of coronary flow with myocardial tissue characterization by CT may be attractive allowing triple assessment by CT. EXPERT COMMENTARY: The combined use of CTCA and functional assessment of coronary artery stenosis by CT perfusion or CT-derived fractional flow reserve is an attractive diagnostic pathway that requires further evaluation.

Type: Article
Title: Functional assessment of coronary artery disease by cardiac computed tomography
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/14779072.2017.1359087
Publisher version: https://doi.org/10.1080/14779072.2017.1359087
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cardiac computed tomography, myocardial perfusion imaging, CT FFR
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10049613
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