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Two-pore channels and disease

Patel, S; Kilpatrick, BS; (2018) Two-pore channels and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , 1865 (11 Pt. B) pp. 1678-1686. 10.1016/j.bbamcr.2018.05.004. Green open access

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Abstract

Two-pore channels (TPCs) are Ca2+-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca2+ from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca2+ changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease phenotypes. We cover evidence from models of Parkinson's disease, non-alcoholic fatty liver disease, Ebola infection, cancer, cardiac dysfunction and diabetes. A need for more drugs targeting TPCs is identified.

Type: Article
Title: Two-pore channels and disease
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbamcr.2018.05.004
Publisher version: https://doi.org/10.1016/j.bbamcr.2018.05.004
Language: English
Additional information: Copyright © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
Keywords: Ca(2+), Lysosomes, NAADP, TPCN1, TPCN2
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10049522
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