Vyas, KN;
Grootendorst, M;
Mertzanidou, T;
MacHoll, S;
Stoyanov, D;
Arridge, SR;
Tuch, DS;
(2018)
Flexible scintillator autoradiography for tumor margin inspection using 18F-FDG.
In:
(Proceedings) SPIE BiOS, 2018 - Molecular-Guided Surgery: Molecules, Devices, and Applications IV.
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Abstract
Autoradiography potentially offers high molecular sensitivity and spatial resolution for tumor margin estimation. However, conventional autoradiography requires sectioning the sample which is destructive and labor-intensive. Here we describe a novel autoradiography technique that uses a flexible ultra-thin scintillator which conforms to the sample surface. Imaging with the flexible scintillator enables direct, high-resolution and high-sensitivity imaging of beta particle emissions from targeted radiotracers. The technique has the potential to identify positive tumor margins in fresh unsectioned samples during surgery, eliminating the processing time demands of conventional autoradiography. We demonstrate the feasibility of the flexible autoradiography approach to directly image the beta emissions from radiopharmaceuticals using lab experiments and GEANT-4 simulations to determine i) the specificity for 18 F compared to 99m Tc-labeled tracers ii) the sensitivity to detect signal from various depths within the tissue. We found that an image resolution of 1.5 mm was achievable with a scattering background and we estimate a minimum detectable activity concentration of 0.9 kBq/ml for 18 F. We show that the flexible autoradiography approach has high potential as a technique for molecular imaging of tumor margins using 18 F-FDG in a tumor xenograft mouse model imaged with a radiation-shielded EMCCD camera. Due to the advantage of conforming to the specimen, the flexible scintillator showed significantly better image quality in terms of tumor signal to whole-body background noise compared to rigid and optimally thick CaF 2 :Eu and BC400. The sensitivity of the technique means it is suitable for clinical translation.
| Type: | Proceedings paper |
|---|---|
| Title: | Flexible scintillator autoradiography for tumor margin inspection using 18F-FDG |
| Event: | SPIE BiOS, 2018 - Molecular-Guided Surgery: Molecules, Devices, and Applications IV |
| ISBN-13: | 9781510614413 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2289693 |
| Publisher version: | https://doi.org/10.1117/12.2289693 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10049243 |
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