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Compressive Strength of Bioactive Sol-Gel Glass Foam Scaffolds

Poologasundarampillai, G; Lee, PD; Lam, C; Kourkouta, A-M; Jones, JR; (2016) Compressive Strength of Bioactive Sol-Gel Glass Foam Scaffolds. International Journal of Applied Glass Science , 7 (2) pp. 229-237. 10.1111/ijag.12211. Green open access

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Abstract

Larry Hench's 45S5 Bioglass® has been used in more than a million patients as a synthetic bone graft, in the form of a particulate. Bioglass is able to stimulate more bone regeneration than other bioactive ceramics. However, it is not commercially available as a porous scaffold with amorphous glass structure because the 45S5 composition crystallizes during sintering. The sol–gel foaming process was developed in Hench's laboratory to overcome this problem. Here, we concisely review the work on scaffold development from Hench's group and report new data that show maximum compressive strengths in excess of 5 MPa can be achieved while maintaining the interconnected pore networks required for vascularized bone ingrowth. This was achieved through optimization of sintering of the sol–gel foams. Sintering of the sol–gel foams was correlated to the network connectivity and silanol content. Changes in strength after immersion in simulated body fluid were found to be small over the times investigated. Relating the dissolution results to in vivo studies indicates that the scaffolds degrade more rapidly in vivo than in vitro.

Type: Article
Title: Compressive Strength of Bioactive Sol-Gel Glass Foam Scaffolds
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ijag.12211
Publisher version: http://dx.doi.org/10.1111/ijag.12211
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bioglass, Larry Hench, sol‐gel, bioactive glass, scaffold
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10049210
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