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Prolonging disuse in aged mice amplifies cortical but not trabecular bones' response to mechanical loading

De Souza, R; Javaheri, B; Collinson, RS; Chenu, C; Shefelbine, SJ; Lee, PD; Pitsillides, AA; (2017) Prolonging disuse in aged mice amplifies cortical but not trabecular bones' response to mechanical loading. Journal of Musculoskeletal Neuronal Interactions , 17 (3) pp. 218-225. Green open access

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Abstract

OBJECTIVE: Short-term neurectomy-induced disuse (SN) has been shown to restore load responses in aged mice. We examined whether this restoration was further enhanced in both cortical and trabecular bone by simply extending the SN. METHODS: Following load:strain calibration, tibiae in female C57BL/J6 mice at 8, 14 and 20 weeks and 18 months (n=8/ group) were loaded and bone changes measured. Effects of long-term SN examined in twenty-six 18 months-old mice, neurectomised for 5 or 100 days with/without subsequent loading. Cortical and trabecular responses were measured histomorphometrically or by micro-computed tomography. RESULTS: Loading increased new cortical bone formation, elevating cross-sectional area in 8, 14 and 20 week-old (p <0.05), but not 18 month-old aged mice. Histomorphometry showed that short-term SN reinstated load-responses in aged mice, with significant 33% and 117% increases in bone accrual at 47% and 37%, but not 27% of tibia length. Cortical responses to loading was heightened and widespread, now evident at all locations, following prolonged SN (108, 167 and 98% at 47, 37 and 27% of tibial length, respectively). In contrast, loading failed to modify trabecular bone mass or architecture. CONCLUSIONS: Mechanoadaptation become deficient with ageing and prolonging disuse amplifies this response in cortical but not trabecular bone.

Type: Article
Title: Prolonging disuse in aged mice amplifies cortical but not trabecular bones' response to mechanical loading
Open access status: An open access version is available from UCL Discovery
Publisher version: https://www.ncbi.nlm.nih.gov/pmc/journals/3115/
Language: English
Additional information: This is an open access article distributed under the terms of the Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported licence (https://creativecommons.org/licenses/by-nc-sa/3.0/).
Keywords: Mechanical Loading, Osteoporosis, Sciatic Neurectomy, Bone, Ageing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10049151
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