Santos e Sousa, P;
Bennett, CL;
Chakraverty, R;
(2018)
Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease.
Frontiers In Immunology
, 9
, Article 963. 10.3389/fimmu.2018.00963.
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Abstract
The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resistance occurs or why there is often a permanent failure to restore tissue homeostasis. Emerging data suggest that the unique immune microenvironment in the skin is responsible for defining location- and context-specific mechanisms of injury that are distinct from those involved in other target organs. In this review, we address recent advances in our understanding of GVHD biology in the skin and outline the new research themes that will ultimately enable design of precision therapies.
| Type: | Article |
|---|---|
| Title: | Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2018.00963 |
| Publisher version: | https://doi.org/10.3389/fimmu.2018.00963 |
| Language: | English |
| Additional information: | Copyright © 2018 Santos e Sousa, Bennett and Chakraverty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | cutaneous graft-versus-host disease, pathophysiology, T cells, antigen-presenting cells, B cells, repair mechanisms, microbiome |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048978 |
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