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Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska, P; Alitalo, K; Allen, E; Anisimov, A; Aplin, AC; Auerbach, R; Augustin, HG; ... Griffioen, AW; + view all (2018) Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis 10.1007/s10456-018-9613-x. (In press). Green open access

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Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Type: Article
Title: Consensus guidelines for the use and interpretation of angiogenesis assays.
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10456-018-9613-x
Publisher version: https://doi.org/10.1007/s10456-018-9613-x
Language: English
Additional information: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Angiogenesis, Aortic ring, Chorioallantoic membrane (CAM), Corneal angiogenesis, Endothelial cell migration, Hindlimb ischemia, Intussusceptive angiogenesis, Microfluidic, Myocardial angiogenesis, Plug assay, Proliferation, Recombinant proteins, Retinal vasculature, Tip cells, Vascular network, Vessel co-option, Zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10048932
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