Dols, A;
Bouckaert, F;
Sienaert, P;
Rhebergen, D;
Vansteeiandt, K;
ten Kate, M;
de Winter, F-L;
... Stek, ML; + view all
(2017)
Early- and Late-Onset Depression in Late Life: A Prospective Study on Clinical and Structural Brain Characteristics and Response to Electroconvulsive Therapy.
The American Journal of Geriatric Psychiatry
, 25
(2)
pp. 178-189.
10.1016/j.jagp.2016.09.005.
Preview |
Text
Barkhof_Dols-EOvsLO LLD MODECT 19052016.pdf - Accepted Version Download (236kB) | Preview |
Abstract
OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study. Clinical profile and somatic health were assessed. Magnetic resonance imaging (MRI) scans were performed before the first ECT and visually rated. RESULTS: Response rate was 78.2% and similar between the two sites but significantly higher in LOD compared with EOD (86.9 versus 67.3%). Clinical, somatic, and brain characteristics were not different between EOD and LOD. Response to ECT was associated with late age at onset and presence of psychotic symptoms and not with structural MRI characteristics. In EOD only, the odds for a higher response were associated with a shorter index episode. CONCLUSION: The clinical profile, somatic comorbidities, and brain characteristics in LLD were similar in EOD and LOD. Nevertheless, patients with LOD showed a superior response to ECT compared with patients with EOD. Our results indicate that ECT is very effective in LLD, even in vascular burdened patients.
| Type: | Article |
|---|---|
| Title: | Early- and Late-Onset Depression in Late Life: A Prospective Study on Clinical and Structural Brain Characteristics and Response to Electroconvulsive Therapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jagp.2016.09.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.jagp.2016.09.005 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Gerontology, Psychiatry, Depression, electroconvulsive therapy, response, late life, early onset, late onset, structural brain, INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW, WHITE-MATTER HYPERINTENSITIES, TEMPORAL-LOBE ATROPHY, MAJOR DEPRESSION, GERIATRIC DEPRESSION, CORTICAL ATROPHY, ELDERLY-PATIENTS, DSM-IV, ECT, MELANCHOLIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048903 |
Archive Staff Only
 |
View Item |
