Patronis, A;
Richardson, RA;
Schmieschek, S;
Wylie, BJN;
Nash, RW;
Coveney, PV;
(2018)
Modeling Patient-Specific Magnetic Drug Targeting Within the Intracranial Vasculature.
Frontiers In Physiology
, 9
, Article 331. 10.3389/fphys.2018.00331.
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Abstract
Drug targeting promises to substantially enhance future therapies, for example through the focussing of chemotherapeutic drugs at the site of a tumor, thus reducing the exposure of healthy tissue to unwanted damage. Promising work on the steering of medication in the human body employs magnetic fields acting on nanoparticles made of paramagnetic materials. We develop a computational tool to aid in the optimization of the physical parameters of these particles and the magnetic configuration, estimating the fraction of particles reaching a given target site in a large patient-specific vascular system for different physiological states (heart rate, cardiac output, etc.). We demonstrate the excellent computational performance of our model by its application to the simulation of paramagnetic-nanoparticle-laden flows in a circle of Willis geometry obtained from an MRI scan. The results suggest a strong dependence of the particle density at the target site on the strength of the magnetic forcing and the velocity of the background fluid flow.
| Type: | Article |
|---|---|
| Title: | Modeling Patient-Specific Magnetic Drug Targeting Within the Intracranial Vasculature |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphys.2018.00331 |
| Publisher version: | https://doi.org/10.3389/fphys.2018.00331 |
| Language: | English |
| Additional information: | Copyright © 2018 Patronis, Richardson, Schmieschek, Wylie, Nash and Coveney. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | magnetic drug targeting, particle suspension, blood flow, lattice-Boltzmann method, multiscale, HemeLB |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048835 |
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