UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Resolution of cystoid macular edema following arginine-restricted diet and vitamin B6 supplementation in a case of gyrate atrophy.

Casalino, G; Pierro, L; Manitto, MP; Michaelides, M; Bandello, F; (2018) Resolution of cystoid macular edema following arginine-restricted diet and vitamin B6 supplementation in a case of gyrate atrophy. Journal of AAPOS 10.1016/j.jaapos.2017.12.016. (In press). Green open access

[thumbnail of Michaelides_JAAPOS_2017_402_copyedited.tk.wvg_GC.pdf]
Preview
Text
Michaelides_JAAPOS_2017_402_copyedited.tk.wvg_GC.pdf - Accepted Version

Download (183kB) | Preview

Abstract

We report the outcome of 3 years of arginine-restricted diet and vitamin B6 supplementation in a boy who presented with gyrate atrophy of the choroid and retina and bilateral cystoid macular edema. The diagnosis of gyrate atrophy was made on the basis of clinical findings and increased plasma ornithine levels. Molecular genetic testing revealed a disease-causing homozygous mutation in the ornithine aminotransferase (OAT) gene. After 3 months of dietary modification and pyridoxine supplementation, visual acuity improved, and optical coherence tomography showed resolution of cystoid macular edema in both eyes. This anatomical and functional improvement was maintained during 3 years of follow-up.

Type: Article
Title: Resolution of cystoid macular edema following arginine-restricted diet and vitamin B6 supplementation in a case of gyrate atrophy.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jaapos.2017.12.016
Publisher version: https://doi.org/10.1016/j.jaapos.2017.12.016
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10048784
Downloads since deposit
128Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item