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Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study

Chouliaras, L; Pishva, E; Haapakoski, R; Zsoldos, E; Mahmood, A; Filippini, N; Burrage, J; ... Ebmeier, KP; + view all (2018) Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study. Epigenomics , 10 (5) pp. 585-595. 10.2217/epi-2017-0132. Green open access

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Abstract

AIM: The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging. METHODS: We tested the association between blood genome-wide DNAm profiles using the Illumina 450K arrays, cognitive dysfunction and brain MRI measures in selected participants of the Whitehall II imaging sub-study. RESULTS: Eight differentially methylated regions were associated with cognitive impairment. Accelerated aging based on the Hannum epigenetic clock was associated with mean diffusivity and global fractional anisotropy. We also identified modules of co-methylated loci associated with white matter hyperintensities. These co-methylation modules were enriched among pathways relevant to β-amyloid processing and glutamatergic signaling. CONCLUSION: Our data support the notion that blood DNAm changes may have utility as a biomarker for cognitive dysfunction and brain aging.

Type: Article
Title: Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/epi-2017-0132
Publisher version: http://doi.org/10.2217/epi-2017-0132
Language: English
Additional information: Copyright © Author(s) This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: DNA methylation, MCI, MRI, brain aging, epigenetic clock, mild cognitive impairment, peripheral biomarker
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10048605
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