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Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome

Dubourg, L; Vrticka, P; Debbane, M; Chambaz, L; Eliez, S; Schneider, M; (2018) Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders , 10 , Article 13. 10.1186/s11689-018-9232-2. Green open access

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Abstract

BACKGROUND: Social impairments are described as a common feature of the 22q11.2 deletion syndrome (22q11DS). However, the neural correlates underlying these impairments are largely unknown in this population. In this study, we investigated neural substrates of socio-emotional perception. METHODS: We used event-related functional magnetic resonance imaging (fMRI) to explore neural activity in individuals with 22q11DS and healthy controls during the visualization of stimuli varying in social (social or non-social) or emotional (positive or negative valence) content. RESULTS: Neural hyporesponsiveness in regions of the default mode network (inferior parietal lobule, precuneus, posterior and anterior cingulate cortex and frontal regions) in response to social versus non-social images was found in the 22q11DS population compared to controls. A similar pattern of activation for positive and negative emotional processing was observed in the two groups. No correlation between neural activation and social functioning was observed in patients with the 22q11DS. Finally, no social × valence interaction impairment was found in patients. CONCLUSIONS: Our results indicate atypical neural correlates of social perception in 22q11DS that appear to be independent of valence processing. Abnormalities in the social perception network may lead to social impairments observed in 22q11DS individuals.

Type: Article
Title: Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s11689-018-9232-2
Language: English
Additional information: © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, 22q11.2 deletion syndrome, Socio-emotional perception, Default mode network, fMRI, CARDIO-FACIAL SYNDROME, RESTING-STATE NETWORKS, AUTISM SPECTRUM DISORDER, DEFAULT MODE NETWORK, FUNCTIONAL CONNECTIVITY, SYNDROME ASSOCIATIONS, PRODROMAL SYMPTOMS, SOCIAL COGNITION, BRAIN NETWORKS, CHILDREN
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10048552
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