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Reticulospinal Systems for Tuning Motor Commands

Brownstone, RM; Chopek, JW; (2018) Reticulospinal Systems for Tuning Motor Commands. Frontiers in Neural Circuits , 12 , Article 30. 10.3389/fncir.2018.00030. Green open access

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Abstract

The pontomedullary reticular formation (RF) is a key site responsible for integrating descending instructions to execute particular movements. The indiscrete nature of this region has led not only to some inconsistencies in nomenclature, but also to difficulties in understanding its role in the control of movement. In this review article, we first discuss nomenclature of the RF, and then examine the reticulospinal motor command system through evolution. These command neurons have direct monosynaptic connections with spinal interneurons and motoneurons. We next review their roles in postural adjustments, walking and sleep atonia, discussing their roles in movement activation or inhibition. We propose that knowledge of the internal organization of the RF is necessary to understand how the nervous system tunes motor commands, and that this knowledge will underlie strategies for motor functional recovery following neurological injuries or diseases.

Type: Article
Title: Reticulospinal Systems for Tuning Motor Commands
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fncir.2018.00030
Publisher version: https://doi.org/10.3389/fncir.2018.00030
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, locomotion, mesencephalic locomotor region, reticular formation, microcircuits, sleep atonia, MESENCEPHALIC LOCOMOTOR REGION, NUCLEUS RETICULARIS GIGANTOCELLULARIS, SPINAL-CORD ACTIVITIES, BRAIN-STEM, MAUTHNER CELL, COMMISSURAL INTERNEURONS, DISCHARGE PATTERNS, DECEREBRATE CATS, FUNCTIONAL-ORGANIZATION, INHIBITORY MECHANISMS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10048516
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