Boutry,, CM;
Kaizawa, Y;
Schroeder, BC;
Chortos, A;
Legrand, A;
Wang, Z;
Chang, J;
... Bao, Z; + view all
(2018)
A stretchable and biodegradable strain and pressure sensor for orthopaedic application.
Nature Electronics
, 1
pp. 314-321.
10.1038/s41928-018-0071-7.
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Abstract
The ability to monitor, in real time, the mechanical forces on tendons after surgical repair could allow personalized rehabilitation programmes to be developed for recovering patients. However, the development of devices capable of such measurements has been hindered by the strict requirements of biocompatible materials and the need for sensors with satisfactory performance. Here we report an implantable pressure and strain sensor made entirely of biodegradable materials. The sensor is designed to degrade after its useful lifetime, eliminating the need for a second surgery to remove the device. It can measure strain and pressure independently using two vertically isolated sensors capable of discriminating strain as small as 0.4% and the pressure exerted by a grain of salt (12 Pa), without them interfering with one another. The device has minimal hysteresis, a response time in the millisecond range, and an excellent cycling stability for strain and pressure sensing, respectively. We have incorporated a biodegradable elastomer optimized to improve the strain cycling performances by 54%. An in vivo study shows that the sensor exhibits excellent biocompatibility and function in a rat model, illustrating the potential applicability of the device to the real-time monitoring of tendon healing.
| Type: | Article |
|---|---|
| Title: | A stretchable and biodegradable strain and pressure sensor for orthopaedic application |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41928-018-0071-7 |
| Publisher version: | http://doi.org/10.1038/s41928-018-0071-7 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Biomedical engineering, Implants, Rehabilitation, Rheumatology, Sensors and biosensors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048500 |
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