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Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure

Bates, KA; Clare, FC; O'Hanlon, S; Bosch, J; Brookes, L; Hopkins, K; McLaughlin, EJ; ... Harrison, XA; + view all (2018) Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure. Nature Communications , 9 , Article 693. 10.1038/s41467-018-02967-w. Green open access

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Abstract

Host-associated microbes are vital for combatting infections and maintaining health. In amphibians, certain skin-associated bacteria inhibit the fungal pathogen Batrachochytrium dendrobatidis (Bd), yet our understanding of host microbial ecology and its role in disease outbreaks is limited. We sampled skin-associated bacteria and Bd from Pyrenean midwife toad populations exhibiting enzootic or epizootic disease dynamics. We demonstrate that bacterial communities differ between life stages with few shared taxa, indicative of restructuring at metamorphosis. We detected a significant effect of infection history on metamorph skin microbiota, with reduced bacterial diversity in epizootic populations and differences in community structure and predicted function. Genome sequencing of Bd isolates supports a single introduction to the Pyrenees and reveals no association between pathogen genetics and epidemiological trends. Our findings provide an ecologically relevant insight into the microbial ecology of amphibian skin and highlight the relative importance of host microbiota and pathogen genetics in predicting disease outcome.

Type: Article
Title: Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-018-02967-w
Publisher version: https://doi.org/10.1038/s41467-018-02967-w
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, BATRACHOCHYTRIUM-DENDROBATIDIS, SYMBIOTIC BACTERIA, RIBOSOMAL-RNA, IMMUNE DEFENSES, CHYTRID FUNGUS, SEQUENCE DATA, MICROBIOTA, INFECTION, PATHOGEN, FROG
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10048289
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